The objective of present study was to investigate the effect of sintering on sustained release matrix tablets containing ambroxol hydrochloride, dicalcium phosphate, magnesium stearate, talc and using different concentration of various retarding materials such as compritol and HPMC K15M. The tablets were compressed by direct compression method and formulation was sintered at various temperatures and time points. Sintering i.e. application of heat, causes the bonding of adjacent particle surfaces in a mass of powder or in a compact leading to the retardation of drug release. The formulations were sintered by two methods i.e. by employing hot air oven and microwave oven. The sintered tablets were characterized by their physical parameters and in-vitro dissolution tests. FT-IR and differential scanning calorimetry studies ruled out the occurrence of drug interaction after sintering condition. Formulation containing compritol (10.2%) provided the release profile of 12 h when subjected to sintering at 80C for 3 h.
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